Biodosimetric tools for a fast triage of people accidentally exposed to ionising radiation. Statistical and computational aspects.

Biodosimetric tools for a fast triage of people accidentally exposed to ionising radiation.

Optimisation and application of “state-of-the-art” cytogenetic techniques for determining genetic damage in the peripheral blood lymphocytes of individuals and populations occupationally or accidentally exposed to ionising radiation

Epidemiological studies have shown that exposure to ionising radiation may induce malignant diseases in the exposed individual. A recent re-evaluation of the incidence of cancer and leukaemia in populations exposed to ionising radiation has resulted in an international recommendation (ICRP report 6

Protein biomarkers for radiation exposure: towards a proteomic approach as a new investigation tool.

Early biomarkers of radiation injury are critical for triage, treatment, and follow-up of large numbers of people exposed to ionising radiation after terrorist attacks or nuclear accident. Operational monoparametric protein or amino acid biomarkers (amylase, Flt3-Ligand, citrulline) can help for the diagnostic of radiation exposure or injury. However, these biomarkers are not sufficient for a f...

Gamma-H2AX-Based Dose Estimation for Whole and Partial Body Radiation Exposure

Most human exposures to ionising radiation are partial body exposures. However, to date only limited tools are available for rapid and accurate estimation of the dose distribution and the extent of the body spared from the exposure. These parameters are of great importance for emergency triage and clinical management of exposed individuals. Here, measurements of γ-H2AX immunofluorescence by mic...

دزسنجی زیستی با استفاده از سنجش ریزهسته

Rapid development in nuclear industry and medical applications involving radiation sources would increase the potential of exposure to the ionizing radiation. Due to the harmful effects of radiation exposure on the health of radiation workers, rapid dose estimation of the overexposed victims with high accuracy is quite important in taking appropriate medical treatment plan. Biological dosimetry...